It is a textural index that evaluates pixel greylevel variations in the lumbar spine dxa image, thereby providing an indirect index of trabecular microarchitecture 11. The range of youngs modulus for trabecular bone is 80014000 mpa and the strength of failure is 1100 mpa. Trabecular bone score tbs is a novel graylevel textural analysis. In girls, tbs value using ba is constant until age 8, and in boys until age 10, and then starts to increase steadily. Medical use medimaps group we understand bone health. Recent data demonstrate the potential utility of the trabecular bone score adjustment of afr through the frax algorithm in subjects with ckd. A study of the value of trabecular bone score in fracture. The trabecular bone score is a measure of grey scale homogeneity obtained from spine dxa, which correlates to trabecular microarchitecture and is an independent risk factor for fracture. Didier hans center for bone diseases, dal lausanne university hospital, switzerland. There is a new bone texture parameter called tbs trabecular bone score, available now to add to your dxa bone density system with the software tbs insight. Cross sectional and prospective studies, involving a large number of subjects, have.
Published articles in english and french were extracted. Review of the scientific evidence regarding clinical use. Assessment of fat distribution and bone quality with. The main aim of this work was to report on trabecular bone score tbs by dualenergy xray absorptiometry dxa of healthy italian subjects to be used as a reference standard for future study in clinical and research settings. Tbs can be readily applied to a dxa image through the use of a specific software, and has an attractive feature which is the possibility of being retrospectively cal culated from an existing dxa image without the need for further imaging 12. The association between trabecular bone score and incident fractures in adults with reduced kidney function and whether this association differs from that of adults with normal. The association between trabecular bone score and incident fractures in adults with reduced kidney function and whether this association differs from that of. Trabecular bone score validated as standalone predictor of fracture risk. Over the past 5 years, numerous publications, communications in congresses and meetings of scientific societies have been generated.
To better understand the potential clinical utility of tbs in smokers, the. An additional software to further analyze the dxa images of the spine is known as trabecular bone score tbs. Explore our dxa and qus bone and metabolic health portfolio by learning more about our products and clinical applications. It computes a trabecular bone score tbs, which provides extremely useful additional clinical information as to the microarchitecture of the bone. Mar 10, 2015 frax is widely used to evaluate fracture risk of individuals in clinical settings. Trabecular bone score in active or former smokers with and without. Trabecular bone score tbs from fracture prediction to clinical use teheran may 2016 prof. Evaluation of the potential use of trabecular bone score to complement bone mineral density in the diagnosis of osteoporosis. Trabecular bone score tbs uses standard lumbar spine dxa imaging to assess bone texture inhomogeneity that is, the number of filled versus unfilled voxels in order to gauge bone quality and fracture risk.
Trabecular bone score or tbs provides information about the quality of bone structure in the spine bone. A new approach for measuring the trabecular bone density. Calculated by tbs insight software which installs on existing dxa scanners, tbs is a simple method that estimates fracture risk based on a determination of bone texture an index correlated to bone microarchitecture. Pothuaud l, barthe n, krieg ma, mehsen n, carceller p, hans d. Search strategy a medline search for publications with the terms trabecular bone score or tbs was undertaken in september 2014. Ge healthcare is a market leader in bone health and metabolic health. Trabecular bone score as an assessment tool to identify. Trabecular bone score tbs is a softwarebased tool for the analysis of dxa images to assess bone microarchitecture in the lumbar region. Commons attribution license, which permits use, distribution and reproduction in any. Frequency of osteoporotic fractures, parameters of bone. Trabecular bone score and incident fragility fracture risk in. A low tbs value has been independently associated with increased fracture risk. Trabecular bone score, a bone microarchitecture index, may improve frax prediction accuracy for major osteoporotic fractures in communitydwelling elderly japanese men.
The role of trabecular bone score and hip geometry in. Apr 26, 2016 one of the most recent and extensively studied determinants of fracture risk is trabecular bone score tbs. This feature was built based on a prospective study of more than 30,000 patients and. Preoperative bone health assessment and the potential use. The trabecular bone score tbs is a recently developed skeletal score that is derived from lumbar spine dual energy xray absorptiometry dxa images. The tbs is used to evaluate pixel gray level variations in the spine on dxa images and is related to bone microarchitecture and fracture risk, thereby providing information independent of bmd. It is measured by evaluating graylevel variations in the pixels of an anteriorposterior lumbar spine dxa scan. Trabecular bone score tbs uses standard dual energy xray absorptiometry to. The trabecular bone score tbs is a new parameter that is determined from graylevel analysis of dualenergy xray absorptiometry dxa images. High tbs degraded trabecular bone architecture heterogeneous. Microstructural parameters of bone evaluated using hrpqct correlate with the dxaderived cortical index and the trabecular bone score in a cohort of randomly.
Thats why bone densitometry has evolved significantly over the past few years. Over the past several years, the hardware and software. Trabecular bone score tbs as a new complementary approach. Background and objectives trabecular bone score is a graylevel textural measure obtained from dual energy xray absorptiometry lumbar spine images that provides information independent of areal bone mineral density. By using the tbs insight software medimapstbs version 1. New fracture risk assessment software available for dxa. Quibim is proud to introduce its new advanced methodolgy to assess bone quality and fracture risk. The trabecular bone score predicts spine fragility fractures in. Trabecular bone score validated as standalone predictor of.
This data may help widen tbs use in pediatric populations. Largest study to date investigating the role of tbs in populations worldwide concludes that tbs is a significant and consistent predictor of fracture risk independent of. Trabecular bone score tbs as a new complementary approach for osteoporosis evaluation in clinical practice. Bone mass and quality decline with age, leading to compromised strength and increased fracture risk. Microstructural parameters of bone evaluated using hrpqct. Leveraged first in the field of osteoporosis as the gold standard for bone microarchitecture assessment on dxa in osteoporosis making a difference in patient lives. New fracture risk assessment software available for dxa there is a new bone texture parameter called tbs trabecular bone score, available now to add to your dxa bone density system with the software tbs insight. As a greylevel textural parameter, the tbs yields additional information on bone texture that is independent of areal bone mineral density abmd.
The trabecular bone score tbs is a novel tool used to evaluate bone microarchitecture. Baldini m, grossi e, cappellini md, messina c, marcon a, et al. Trabecular bone score and incident fragility fracture risk. Trabecular bone score as an assessment tool to identify the. Tbs insight software installs on existing dxa scanners. Tbs, which is assessed by lumbar spine dualenergy xray absorptiometry dxa imaging, provides information about the microarchitectural deterioration of bone tissue. A team of international researchers has now validated the predictive ability of trabecular bone score tbs using individuallevel data of 17,809 men and women from 14 studies worldwide.
Trabecular bone score in healthy ageing the british. A trabecula plural trabeculae, from latin for small beam is a small, often microscopic, tissue element in the form of a small beam, strut or rod that supports or anchors a framework of parts within a body or organ. Trabecular bone score tbs uses standard dual energy xray absorptiometry to measure how wellstructured the trabecular bone appears when assessed as individual voxels. Purpose trabecular bone score tbs is a softwarebased method for indirect assessment of trabecular bone structure of the spine, based on analysis of pixels in dual energy xray absorptiometry. This software looks at the distribution of the bone within the vertebral body on a two dimensional image acquired by the dxa machine. Use of dual energy xray absorptiometry, the trabecular. It relies on the mean thickness and volume fraction of trabecular bone microarchitecture. Mar 22, 20 pothuaud l, barthe n, krieg ma, mehsen n, carceller p, hans d.
Trabecular bone score tbs is a recentlydeveloped analytical tool that. Tbs insight bone density software dexa solutions, llc. How it works easily installed on a dxa machine, this software application uses the dxa 2d images produced during a regular spine bone mineral density bmd scan to seamlessly compute a patients trabecular bone score within seconds. Tbs insight serves as a foundation technology for tissue structure assessment software applications. Trabecular bone score tbs is an index of bone microarchitecture that provides additional skeletal information to areal bone mineral density abmd. Trabecular bone score as a supplementary tool for the discri. The measurement is performed seamlessly using dxa images acquired from a bone mineral densitometry bmd scan. The measurement is performed using dualenergy xray absorptiometry dxa images acquired from a bone mineral densitometry bmd scan, and results can be interpreted by physicians to.
Since the clinical utility of a diagnostic test is that of adding information to that. The incorporation of new technological applications in the medical field entails a prolonged period of evaluation of the scientific evidence generated in the clinical validation process. Trabecular bone score tbsa novel method to evaluate. The application of the trabecular bone score tbs has also received the. The result is expressed as a trabecular bone score. Trabecular bone score tbs is a software based tool for the analysis of dxa images to assess bone microarchitecture in the lumbar region. The trabecular bone score tbs is a new texture parameter obtained from the analysis of dualenergy xray absorptiometry dxa images. The tbs is a useful additional score of bone health, which may help to better define fracture risk. We examined whether trabecular bone score tbs predicts the risk of vertebral fractures in a japanese female cohort. Trabecular bone scan tbs insight is an imaging software application that assesses bone texture which in turn is expressed as the trabecular bone score tbs. A trabecula generally has a mechanical function, and is usually composed of dense collagenous tissue such as the trabecula of the spleen. To do so, tbs utilizes a software program installed on a standard dxa computer to.
Moreover, longitudinal and prospective studies have suggested that the tbs is. Tbs insight is a unique, easytouse software application that assesses bone texture an index of bone microarchitecture which in turn is expressed as the trabecular bone score tbs. The trabecular bone score tbs is a graylevel textural metric that can be extracted. A recently developed diagnostic tool, trabecular bone score tbs, can provide quality of trabecular microarchitecture based on images obtained from dualenergy xray absorptiometry dxa. Trabecular bone score tbsa novel method to evaluate bone. The result expressed as a trabecular bone score tbs derives from a patented algorithm that evaluates pixel graylevels and spatial variations in the ap spine dxa scan, providing an indirect, yet highly. Evaluation of the potential use of trabecular bone score to.
Since patients receiving glucocorticoid are at a higher risk of developing secondary osteoporosis, assessment of bone microarchitecture may be used to evaluate risk of fragility fractures of osteoporosis. The relationship between modulus of trabecular bone and its apparent density was demonstrated by carter and hayes in 1976. However, frax prediction accuracy is not sufficient, and improvement is desired. Assessment of fat distribution and bone quality with trabecular bone score tbs in healthy chinese men skip to main content thank you for visiting. The trabecular bone score is a measure of bone texture correlated with bone microarchitecture and a marker for the risk of osteoporosis. Trabecular bone score page 1 of 2 trabecular bone score or tbs provides information about bone structure that complements bone density measurement, and can be conveniently measured during a standard bone density test we are. Simulated increased soft tissue thickness artefactually. Trabecular bone score tbs as a new complementary approach for. Trabecular bone score as a supplementary tool for the. A consensus report of a european society for clinical and economic aspects of osteoporosis and osteoarthritis esceo working group.
Thats why bone densitometry has evolved significantly over the past few. Potential sources of this ageassociated decline in bone quality include. Assessing bone quality and fracture risk in patients with osteoporosis in 2012 the fda approved a new diagnostic tool for assessing fracture risk in people with osteoporosis. The need for a reliable approach for the characterization of trabecular microarchitecture is evident, as conditions and diseases related to trabecular bone quality and structure are becoming a focal point of precision medicine. One such parameter is trabecular microarchitecture, including trabecular distribution and connectivity, which can be indirectly measured by trabecular bone score tbs. It is conveniently measured during a standard bone density test. Tbs can be readily applied to a dxa image through the use of a specific software. A preliminary spine bmd matched, casecontrol study author links open overlay panel laurent pothuaud 1 2 nicole barthe 3 4 marcantoine krieg 2 nadia mehsen 5 pascal carceller 1 didier hans 2. The trabecular bone score tbs is a textural measurement derived from lumbar spine d ualenergy xray absorptiometry dxa images.
We offer dxa and ultrasonometer systems for a wide range of clinical and research applications. Crosssectional and prospective studies, involving a large number of subjects, have. As mentioned above, the mechanical properties of trabecular bone are very sensitive to apparent density. One of the most recent and extensively studied determinants of fracture risk is trabecular bone score tbs. Trabecular bone score may improve frax prediction accuracy for major osteoporotic fractures in elderly japanese men. Trabecular bone score may improve frax prediction accuracy. This information complements bone mineral density measurement, and can be helpful to clinicians in determining fracture risk and discussing lifestyle management or treatment options with patients. Tbs is related to bone microarchitecture and provides skeletal information that is not captured from the standard bone mineral density bmd measurement. Using the trabecular bone score tbs application, you can also study the bone quality and the bone microarchitecture of the bone to achieve added clinical diagnostic confidence.
Jun 03, 2015 new fracture risk assessment software available for dxa there is a new bone texture parameter called tbs trabecular bone score, available now to add to your dxa bone density system with the software tbs insight. Dual energy xray absorptiometry dxa is considered the most highly developed and most thoroughly validated technique for assessing bone mineral density, according to the world health organizations report on the prevention and. It is an index of bone microarchitecture that provides skeletal information complementary to that obtained from standard bone mineral density bmd measurement. Pdf trabecular bone score may improve frax prediction.
Trabecular bone score tbs from fracture prediction to clinical use teheran may 2016. Introduced in 2008, its main projected use is alongside measures of bone density in better predicting fracture risk in people with metabolic bone problems. Mar 31, 2016 trabecular bone score or tbs provides information about the quality of bone structure in the spine bone. Trabecular bone score tbs is a novel texture parameter to evaluate bone. Trabecular bone score no units the trabecular bone score tbs is an indirect measure of the microarchitecture of the trabeculae, or lattice structures, that compose the trabecular spongy bone in the lumbar spine. Use of dual energy xray absorptiometry, the trabecular bone. As you know, osteoporosis diagnosis and management remain a challenge.
Recently tbs data has been used to optimize the fracture risk assessment tool frax predictive value. The trabecular bone score tbs uses twodimensional scans obtained during. Trabecular bone score tbs predicts vertebral fractures. Apr 26, 2016 assessment of fat distribution and bone quality with trabecular bone score tbs in healthy chinese men skip to main content thank you for visiting. Trabecular bone score tbs is a novel method for indirectly assessing. The output of frax can now be adjusted for trabecular bone score tbs. Reference ranges for trabecular bone score in australian men. A new approach for measuring the trabecular bone density through the echosound backscattering. The aim of this study was to evaluate the clinical value of tbs on frax algorithm. Trabecular bone score tbs predicts vertebral fractures in. Bone age as a correction factor for the analysis of.
The trabecular bone score tbs is a new method to describe skeletal. Since that time, trabecular bone score tbs has rapidly made its way into the clinical setting. Evaluation of the potential use of trabecular bone score. Bone strength is predominantly determined by bone density, but bone microarchitecture also plays an important role. Effects of teriparatide, denosumab, or both on spine. Trabecular bone score page 1 of 2 osteoconnections. Pothuaud l, barthe n, krieg ma, mehsen n, carceller p, et al.
516 443 795 1245 1229 685 1539 378 25 791 110 925 799 341 1059 767 205 109 946 81 326 596 459 174 959 922 52 989 941 437 247 1317 270 813 1451 135 676 1022